Photo of Yi-Hsiang Hsu, MD at the Hinda and Arthur Marcus Institute for Aging Research in Boston, MA

Yi-Hsiang Hsu, MD, ScD

  • Associate Scientist
  • Assistant Professor of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center
  • Faculty

Dr. Hsu’s research focuses on (1) genetic contribution of common aging relevant disorders using population-based next generation whole genome sequencing, exome-sequencing and GWAS approaches; (2) statistical method development on multiple-phenotype association analyses; and (3) identifying biomarkers of osteoporosis using metabolomics.

Research Areas

Learn more about the areas of research where Dr. Hsu focuses.

A researcher at the Marcus Institute for Aging Research in Boston, MA holds a vial of blood.

Biomarkers and Genetics

As precision medicine enters the mainstream of clinical care, Marcus Institute researchers are working to advance the understanding of disease biomarkers and genetics.

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A researcher at the Marcus Institute for Aging Research in Boston, MA studies MRI images of a human brain.

Brain Health

Through pioneering multidisciplinary research, the Marcus Institute is uncovering new answers to the challenges of Alzheimer’s disease, dementia, delirium, and other changes to the brain.

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A string of computer code is reflected in the glasses of a researcher at the Marcus Institute for Aging in Boston, MA.

Data Science and Technology

The Marcus Institute includes a biostatistics and data sciences faculty who collaborate with investigators to design and conduct clinical trials and observational studies in aging.

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A close-up shot at two hands holding a syringe that is inserted in a vial of medication.


Marcus Institute researchers are examining the relationship between medicine and adverse health outcomes such as falls, injuries, and treatment side effects among older people.

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A research subject at the Marcus Institute for Aging Research stands on a measuring platform with a computer read-out reflected on the wall behind.

Physical Health and Function

Through the Marcus Institute’s research we are learning how older adults can maintain independence and quality of life.

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Current Projects

View Dr. Hsu's current projects.

Identifying Osteoporosis Genes by Whole Genome Sequencing and Functional Validation in Zebra Fish

This research aims to identify potential causal-variants and their targeted genes via fine-mapping on previously reported GWAS loci of osteoporosis and identify potential targets for osteoporosis and osteoporotic fractures therapy.

NIH R01AR072199

Principal Investigator