Joint Hypermobility and Lower Body Osteoarthritis
The overall goal of this project is to define the contribution of joint hypermobility to lower body osteoarthritis (OA).
Foot Disorders, Pain and Physical Disability in Older Persons: the Framingham Foot Study
NIAMS R01 AR047853
The overall goal of this project is to examine the effect of age, sex, and race upon biomechanical foot measures, and to examine the relation of these measures to lower extremity limitations and functional disabilities in two, large population-based cohorts of older adults. This renewal five-year NIH grant builds upon a previous five-year project that examined specific foot disorders. Over 3,000 adults are enrolled in these cohorts, incorporating information from diverse environments (urban vs. rural) and from various racial/ethnic groups.
Genetics of Foot Disorders
NIAMS R01 AR060492
This grant will examine the heritability of specific foot disorders and conduct GWAS of foot disorders and foot biomechanics in two large population-based cohorts, the Framingham Study and Johnston County OA Project. Meta-analyses across the known cohorts with these phenotypes will be conducted and SNP findings will be replicated in other cohorts with foot and genetic data. This is the first human GWAS of foot disorders and the investigators welcome contact from others across the world interested in the genetics of foot disorders in populations.