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Aging Muscle Current Research Projects

Novel risk factors for muscle mass and muscle strength in adults  
NIA/NIH 1R01AG051728-01A1

The goal of this proposal is to determine the roles of antioxidant intake, endothelial function, aortic stiffness and mitochondrial dysfunction in loss of muscle mass and strength, gait speed, and muscle quality in adults from the Framingham Offspring Study. We will further determine the combined effect of these novel risk factors on baseline measures of lean mass and upper extremity muscle quality, and with change in grip strength and gait speed over time using a theoretically based model.


The Mediterranean diet, related antioxidants and frailty 
Boston Claude D. Pepper Center Older American Independence Centers (OAIC; 1P30AG031679)

The goal of this project is to determine the role of the Mediterranean diet (a diet rich in fruits, vegetables, and dietary antioxidants) on the risk of frailty, and whether specific dietary antioxidants (vitamin C, E, and carotenoids) represent an important part of the potential biologic pathway involving the Mediterranean diet and frailty.

Risk Factors for Age Related Bone Loss
NIAMS R01 AR41398
This is the original Framingham Osteoporosis Study grant that began in 1991. This project will determine the association of visceral adiposity with trunk muscle density measured using QCT scans in the Framingham Study Third Generation cohort.  The hypotheses are that greater amounts of visceral adiposity will be associated with lower trunk muscle density, and this association will be partly explained by levels of physical activity, inflammation, adipokines, or sex steroid metabolism.  The study will also examine whether increases in visceral adiposity leads to the development of lower density muscle.   
Dairy food intake, related nutrients and frailty
National Dairy Council
The goal of this project is to determine the role of dairy foods intake on the risk of frailty over time, and whether dairy specific nutrients such as dietary protein, calcium, and vitamin D represent an important part of the biologic pathway involving dairy food intake and frailty.
The effect of sodium reduction on blood pressure and physical function in older adults: Satter hOuse Trial of Reduced sodiUm mEals (SOTRUE)
Interventional Studies in Aging Center, Marcus Institute, Hebrew SeniorLife; NCT04074941
The goal of this pilot study is to determine the effects of a low sodium (<2.3 g/d), 2-week meal plan compared with a usual meal plan (average sodium >4.5 g/d) on seated blood pressure among independently living older adults using an individual level, parallel RCT.