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Aging Muscle Current Research Projects

Novel risk factors for muscle mass and muscle strength in adults  
NIA/NIH 1R01AG051728-01A1

The goal of this proposal is to determine the roles of antioxidant intake, endothelial function, aortic stiffness and mitochondrial dysfunction in loss of muscle mass and strength, gait speed, and muscle quality in adults from the Framingham Offspring Study. We will further determine the combined effect of novel (antioxidants, vascular function and mitochondrial DNA copy number) and established (protein intake, inflammation and physical activity) risk factors on baseline measures of lean mass and upper extremity muscle quality, and with change in grip strength and gait speed over time using a theoretically based model.

The relation of fat distribution with muscle health and the role of adipokines
NIA/NIH R03AG053679 

The goal of this project is to determine the cross-sectional association of abdominal fat distribution with muscle mass, strength, strength-to-mass ratio (muscle quality), and physical performance, and whether adipocytokines partly explain these associations.

Risk Factors for Age Related Bone Loss
NIAMS R01 AR41398
This is the original Framingham Osteoporosis Study grant that began in 1991. This project will determine the association of visceral adiposity with trunk muscle density measured using QCT scans in the Framingham Study Third Generation cohort.  The hypotheses are that greater amounts of visceral adiposity will be associated with lower trunk muscle density, and this association will be partly explained by levels of physical activity, inflammation, adipokines, or sex steroid metabolism.  The study will also examine whether increases in visceral adiposity leads to the development of lower density muscle.