Senolytics to Alleviate Mobility Issues and Neurological Impairment in Aging (STAMINA) Study

Are you age 65 or older and worried about your walking speed or memory?

Study goal:  Senescent (old) cells can accumulate in the body with aging, and may contribute to problems with mobility (walking speed) and memory.  The goal of this study is to determine whether the senolytic medications, Dasatinib and Quercetin, can reduce senescent cells, increase mobility (walking speed), and improve memory in older adults.

Requirements: If you are over age 65 and have concerns about your mobility and memory.

Participation includes:

• Up to 8 visits, one every two weeks, over 14 weeks.
• Eligibility screening visit.
• Health interviews, walking, balance, memory and blood flow assessments at baseline, and follow up visits.
• Blood tests at each visit.
• Two urine tests
• Dasatinib and Quercetin will be given at 6 study visits, visits 2-7, with one dose to take at home the next day following the visit for a total of 12 doses.
• Regular telephone follow up with the study team throughout the study.

Participation is paid up to $300. Free parking and/or transportation provided.

Contact the research team for more info at (617)-971-5688 or email stamina@hsl.harvard.edu